Sinonasal myxoma/fibromyxoma: case report and literature review

Sinonasal myxoma/fibromyxoma is a rare benign neoplasm of uncertain histogenesis which can be locally aggressive. Surgical resection the preferred management. We present case sinonasal fibromyxoma in 30-year-old male who presented with frontal sinus tumour. Histopathological examination showed hypocellular spindle to stellate cell myxoid collagenous background, without nuclear atypia, mitoses or necrosis. The tumour expressed vimentin, SMA, h-caldesmon and b-catenin (focal). Cytokeratins, EMA, GFAP, S100, MUC4, desmin, myogenin ALK1 were negative. histological differential diagnosis includes: low grade fibrosarcoma, sarcoma (particularly rhabdomyosarcoma, liposarcoma), pleomorphic adenoma inflammatory myofibroblastic SMA staining have been previously reported this entity. significance unclear. Although marker smooth muscle differentiation, there was no morphological evidence considered represent aberrant staining. In conclusion, should neoplasms, after exclusion malignancy on immunohistochemical grounds.